INOFEA’S

TECHNOLOGY PLATFORM

We have developed a unique and patented technology platform that makes enzymes easy to separate after a reaction is completed, to use them in continuous or flow-through reactors, and to avoid enzyme leaching from the carrier they are immobilized on. In small molecule API manufacturing, our technology reduces the number of intermediates and makes them more robust in the presence of organic solvents or other chaotropic conditions, high temperatures, or low and high pH values.

Our technology platform is unlocking the full potential of enzymes, providing a seamless level of enhanced properties, unlike any other existing technology.

Read More on Enzymes
Illustration of molecules on a green background.
Diagram showing the stages of enzyme shielding: carrier, anchored enzyme, shielding, partially shielded enzyme, fully shielded enzyme.

How Does It Work?

INOFEA’s technology uses a flexible step-by-step approach to tailor the conditions of enzyme anchoring and shielding based on the enzyme selected and on the reaction it catalyzes.

Our technology is capable to immobilize any enzyme or cocktail of enzymes onto particles and protect them by growing a structured shield on the outer surface. The protective layer prevents the enzyme denaturation, avoids leaching of the enzyme and provides a remarkable resistance to various process conditions.

Our Shield

Prevents the enzyme denaturation and provides a remarkable resistance to various process conditions, such as

A white syringe inside a white cup on a green circular background.

Wide pH range

Green circular icon with a white thermometer symbol

Temperature

Illustration of a stylized knot with an arrow pointing to a loose loop, all on a green circular background.

Presence of
chaotropic agents

Icon of a laboratory flask with bubbling liquid inside, on a green circular background.

Solvents

OUR POSSIBILITIES

  • Selection of different carriers

  • Covalent and oriented enzyme immobilization

  • Co-immobilization of cocktails of enzymes, enabling cascade reactions

  • Allowing cofactor recycling

  • Tuning of the layer thickness, composition and porosity according to the substrate to be converted

THE BENEFITS

  • No leakage of enzymes

  • Enzyme stabilization

  • Enzyme collection easy after reaction is complete

  • Making implementation in continuous or semicontinuous processes possible

  • Higher process efficiency

  • Improved sustainability (reduced carbon dioxide emission, energy consumption and waste production)

  • Attractive cost saving potentials

  • Faster time to market

Platform Technology